Richard Silverman

Richard Silverman is a Clinical Assistant Professor in the Department of Internal Medicine at Yale School of Medicine, Yale University. His research focuses on neurodegenerative diseases, pain management, medicinal chemistry, and enzymology. He holds an MD from the Autonomous University of Guadalajara (1989) and a BS from SUNY Stony Brook (1985).

His research explores novel therapeutic strategies for Alzheimer’s disease, amyotrophic lateral sclerosis, and pain disorders. Key contributions include developing inhibitors of amyloid beta oligomerization (e.g., NU-9) and GABA aminotransferase inactivators for pain relief. His work also spans organic synthesis methods for complex molecules and mechanistic studies of enzymes like ornithine aminotransferase and nitric oxide synthase.

Recent publications highlight advancements in pyrazolone-based therapeutics for ALS, structural insights into nitric oxide synthase dynamics, and asymmetric synthesis of bioactive compounds. His interdisciplinary approach bridges organic chemistry, biochemistry, and clinical applications.