Richard O. Hynes

Richard O. Hynes is the Daniel K. Ludwig Professor for Cancer Research at MIT's Koch Institute. His work focuses on the role of the extracellular matrix in cancer metastasis, leveraging proteomics and mouse models. He holds the HHMI Investigator title and has received multiple prestigious awards including the Gairdner Foundation International Award and membership in the National Academy of Sciences.

• Affiliations: Koch Institute, MIT Department of Biology
• Education: PhD (1971) and MA (1970) from MIT; BA (1966) from Cambridge University

Research interests center on metastasis mechanisms, particularly how tumor cells interact with the extracellular matrix and surrounding cells. Key contributions include identifying matrix-driven metastatic pathways and developing nanobody-based imaging tools.

Publications highlight ECM proteomics, YAP-driven dissemination, and collagen-mediated metastasis suppression. Awards span decades of recognition in cell biology and cancer research.

Grants: Supported by NCI, NHLBI, and Ludwig Foundation. Lab collaborations involve teams like Carr SA (proteomics) and Tuveson DA (pancreatic cancer).

Lab/Teams: Hynes Lab at Koch Institute, focusing on ECM-cancer interactions and therapeutic applications.