Rebecca Voorhees
Assistant Professor · Molecular Biology
California Institute of Technology (Caltech)About
Rebecca Voorhees
Assistant Professor of Biology and Biological Engineering at the California Institute of Technology (Caltech), Dr. Voorhees is an HHMI Freeman Hrabowski Scholar (2023-) and former HMRI Investigator (2017–2023). She holds a B.S. and M.Sc. from Yale University (2007) and a Ph.D. from the MRC Laboratory of Molecular Biology (2011). Prior to joining Caltech, she was a Visiting Associate (2016–2017).
Research Focus
Her work centers on understanding the molecular mechanisms governing protein homeostasis, particularly the synthesis, localization, assembly, and quality control of membrane proteins. Key areas include:
- Coupled biogenesis and quality control pathways
- ER membrane protein complex (EMC) function
- Mitochondrial outer membrane protein insertion
- Phase-separated condensates in cellular regulation
Methodologies
Her lab employs integrated approaches combining:
- Functional genomics (CRISPRi screens)
- Cryo-electron microscopy
- Structural biology
- Biochemical reconstitution
Awards & Grants
- HHMI Freeman Hrabowski Scholar (2023–)
- NSF CAREER Award (2022)
Labs & Teams
Director of the Voorhees Lab, which focuses on translating molecular insights into strategies for disease intervention.
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