Patricia Grasso

Patricia Grasso is a Professor of Medicine at Albany Medical College, with research expertise in synthetic peptide leptin mimetics and their applications in metabolic and neurocognitive disorders. Her work bridges neuroscience, endocrinology, and pharmacology.

Education

• PhD, Georgetown University School of Medicine (1984)
• MS, The College of St. Rose (1967)
• BA, The College of St. Rose (1962)

Dr. Grasso investigates how synthetic peptide leptin mimetics influence energy expenditure, glucose regulation, lipid metabolism, and cognitive function. Her lab has demonstrated that these peptides can reduce food intake, body weight, and glucose levels while enhancing insulin sensitivity and episodic memory in animal models. Current studies focus on Alzheimer’s Disease (linked to brain insulin resistance), vascular dementia, and Down syndrome.

The recent articles highlight her team’s work on MA-[D-Leu-4]-OB3, showing therapeutic potential in diabetes and neurodegenerative disease models. Key themes include leptin peptide design, metabolic-cognitive interactions, and neuroinflammation.