Pablo E. Castillo

Pablo E. Castillo is a Professor in the Dominick P. Purpura Department of Neuroscience and the Department of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine. He holds the Harold and Muriel Block Chair in Neuroscience. His research focuses on synaptic transmission and plasticity in the mammalian brain, particularly investigating synaptic dysfunction in models of Alzheimer’s disease, epilepsy, autism, schizophrenia, and drug abuse. His work employs electrophysiology, optogenetics, calcium imaging, and mouse models to study neural activity regulation of synaptic strength.

Key research areas include:

• Endocannabinoid signaling mechanisms
• Role of NMDA and kainate receptors in synaptic function
• Neuroplasticity in neuropsychiatric disorders
• Presynaptic protein synthesis and remodeling
• Hippocampal circuit dynamics

Publications highlight contributions to understanding seizure mechanisms, synaptic receptor regulation, and plasticity pathways critical for learning and memory. His findings bridge basic neuroscience with translational insights into neurodegenerative and psychiatric conditions.

Labs/Teams: Active in collaborative neuroscience research groups at Einstein College of Medicine, focusing on synaptic physiology and disease modeling.