Nuno Raimundo

Nuno Raimundo, Ph.D. is an Associate Professor in the Department of Cell and Biological Systems at the Penn State Cancer Institute. His research focuses on mitochondrial dysfunction, lysosomal activities, and their roles in aging and cellular nutrient sensing. Dr. Raimundo leads a research project funded by the National Institute on Aging investigating how mitochondrial malfunction impacts lysosomal pathways and aging processes.

Education & Affiliations:

• Ph.D. in Cellular Biology (not specified)
• Affiliated with Penn State Cancer Institute's Mechanisms of Carcinogenesis division

Research Interests: Explores interorganelle communication, mitochondrial quality control, and lysosomal dynamics using advanced microscopy techniques. Studies include antioxidant effects on energy homeostasis in skin fibroblasts and mechanisms of damaged lysosome clearance through actin remodeling. His work bridges molecular mechanisms with broader implications for aging and cancer biology.

Recent Work Trends: Over 2023-2025, publications emphasize lipid-mediated organelle interactions, mitochondrial-lysosomal crosstalk, and transcription factor regulation of mitochondrial processes. Recent studies in EMBO Journal and Trends in Cell Biology highlight methodological innovations in organelle dynamics observation.

Awards:

• 2024 Dean's Award for Excellence in Teaching (shared with 64 colleagues)

Grants & Projects:

• Principal Investigator (PI) of NIH-funded project: 'Mitochondrial malfunction perturbs lysosomal activities and cellular nutrient sensing pathways' (2023-2024)

Labs & Teams: Leads a multidisciplinary lab investigating mitochondrial dysfunction's role in aging biomarkers, collaborating with institutions in Portugal and the US on lysosomal biology and antioxidant mechanisms.