Nishith Gupta

Nishith Gupta is a Professor specializing in parasitology and biochemistry with a research focus on apicomplexan parasites, particularly Toxoplasma gondii and Eimeria species. His work bridges molecular biology, lipid biochemistry, and host-pathogen interactions to understand the metabolic pathways essential for parasite survival and virulence.

• Humboldt-Universität zu Berlin: Habilitation in Biochemistry (2009-2017)
• Universität Leipzig: PhD in Biochemistry (1999-2003)
• Banaras Hindu University: MS in Biotechnology (1997-1999)
• Banaras Hindu University: Diploma in German Language (1997-1999)
• Rohilkhand University: BS in Biology (1994-1997)

Professor Gupta's research centers on lipid metabolism in apicomplexan parasites, particularly focusing on phospholipid biosynthesis pathways in Toxoplasma gondii. His laboratory investigates how these parasites manipulate host cells, with special emphasis on calcium signaling, cyclic nucleotide pathways, and metabolic adaptations that support intracellular survival. His work has revealed novel drug targets related to phospholipid metabolism and ion homeostasis.

Analysis of his recent publications shows a consistent focus on lipid-dependent processes in parasite biology, with particular attention to phosphatidylserine, phosphatidylethanolamine, and phosphatidylthreonine metabolism. His research demonstrates how these lipids regulate critical processes including host cell invasion, intracellular replication, and egress. The work spans molecular characterization of enzymes to physiological studies of parasite-host interactions.

• Multiple grants from Deutsche Forschungsgemeinschaft (DFG) on phospholipid metabolism in Toxoplasma
• Funding from Helmholtz Association for central carbon metabolism studies
• European Society of Clinical Microbiology and Infectious Diseases grant for drug target research
• Novartis Animal Healthcare contract for anti-Toxoplasma drug screening

Professor Gupta's laboratory has made significant contributions to understanding how apicomplexan parasites manipulate host cells through lipid-mediated signaling. His team has developed innovative approaches including optogenetic tools to study cyclic nucleotide signaling in parasites. Current research focuses on metabolic plasticity, essential pathways for parasite survival, and identifying druggable targets in lipid metabolism.