Nicholas Matheson

Dr. Nicholas Matheson is a researcher at the University of Cambridge's Department of Medicine and a collaborator in the Cambridge Immunology Network. His work focuses on understanding how viruses like HIV and SARS-CoV-2 manipulate host immunometabolism through protein regulation and proteomic analysis.

Research Focus:
Using SILAC and TMT-based proteomics, Matheson investigates how HIV accessory proteins (Vpu, Nef) modulate cell surface nutrient transporters to alter metabolic flux in infected cells. His studies extend to SARS-CoV-2 research, including viral entry mechanisms, immune response heterogeneity, and Long Covid pathogenesis.

Collaborative Themes:
His work spans

• Host-pathogen interactions in T cells
• CRISPR-Cas9 functional genomics
• Immunometabolic regulation
• Extracellular vesicle biology
• Viral entry mechanisms (TMPRSS2, ACE2)