Nicholas Brady

Nicholas Brady is an Assistant Professor of Pathology and Laboratory Medicine at Weill Cornell Medicine's Graduate School of Medical Sciences, where he leads the Brady Lab. The lab focuses on neuroendocrine prostate cancer (NEPC) and lineage plasticity in castration-resistant prostate cancer (CRPC), employing in vitro and in vivo models for mechanistic studies.

Education:

• Bachelor's in Physics from Boston University
• Ph.D. from the University of Minnesota under Dr. Kathryn Schwertfeger, studying mammary gland development and JAK/STAT signaling in breast cancer
• Postdoctoral training at Weill Cornell Medicine with Dr. David Rickman on N-Myc in NEPC

Brady Lab's research investigates chromatin state changes driving NEPC progression and identifies transcriptional regulators cooperating with epigenetic alterations. Current projects include Regulation of chromatin states during progression to NEPC, Identifying novel transcriptional drivers, and Understanding the tumor microenvironment. His work utilizes human prostate cancer cell lines, patient-derived organoids, and transgenic mice with single-cell next-generation sequencing.

Scientific Awards:

• MTOR Training Program Fellow (2018-2019)
• American Cancer Society Postdoctoral Fellowship (2021-2022)
• JumpStart Research Career Development Award (2021-2024)
• NCI Transition Career Development Award (K22) (2024)

Brady's research has been supported by grants including the WCM JumpStart Program, WCM SPORE in Prostate Cancer Career Enhancement Program, and targeted tumor heterogeneity research funding. His publications reflect expertise in chromatin biology, lineage plasticity, and prostate cancer genomics.