About
Dr. Ndaba Mazibuko is a Clinical Research Fellow and Study Clinician in Clinical Neuroscience at the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL). He serves as the Repurposing Lead at the KCL Centre for Innovative Therapeutics (C-FIT) and provides clinical oversight for the Department of Neuroimaging’s research portfolio. He is also an EDI Theme Representative for the NIHR Maudsley Biomedical Research Centre and works clinically as a Staff Grade Clinician at the National Psychosis Unit, South London and Maudsley NHS Trust.
His research interests lie at the intersection of clinical neuroscience, neuroimaging, and neuropsychopharmacology. He specializes in clinical trial design and management, with a focus on repurposing existing therapeutics for psychiatric and neurological conditions. His work investigates the neural mechanisms of psychosis, depression, and neurodegenerative disorders using advanced imaging techniques such as PET and fMRI.
Dr. Mazibuko’s recent publications reflect a strong trend in exploring pharmacological modulation of cerebral blood flow and neural processing. Key themes include the effects of ketamine on reward circuitry in depression, oxytocin’s neurovascular impact, methylene blue’s metabolic effects, and neuroimaging biomarkers in Parkinson’s psychosis and cerebral small vessel disease.
He has contributed to significant research collaborations, including academic-industry clinical trials, and his work has been recognized through citations and media coverage. He has served as a Medical Principal Investigator and contributes to equity and inclusion in research through his EDI role.
Dr. Mazibuko trained in Australia and has clinical experience across the NHS, Africa, and Australia. His prior roles include Neurology and Acute Stroke Registrar at King’s College Hospital, demonstrating a broad clinical foundation in neurology and psychiatry.
