Museog Choe

Museog Choe is a Research Fellow in the Department of Genetics at Yale School of Medicine. His research focuses on stem cell biology, organoid modeling, and their applications in understanding neurological disorders and cancer. He specializes in generating human pluripotent stem cell-derived cerebral organoids to study diseases such as Alzheimer’s and brain metastasis. Key areas include neuronal differentiation mechanisms, gene editing validation, and drug screening platforms using 3D organoid systems. His work bridges developmental biology, genetics, and translational medicine.

Research interests encompass stem cell signaling pathways (e.g., YAP, Wnt/β-catenin), disease modeling (e.g., familial Alzheimer’s, breast cancer metastasis), and the optimization of organoid technologies for studying brain regions like the diencephalon and forebrain. He has developed methodologies to enhance organoid quality and scalability, with applications in drug discovery and understanding neurodegenerative processes.

Publications highlight contributions to stem cell differentiation mechanisms, anticancer drug models, and herbal extract efficacy in osteoarthritis. While no awards are explicitly mentioned, his work demonstrates innovative approaches in regenerative medicine and disease modeling.