Murray Clarke

Professor Murray Clarke is a PHSA-Engage Mutual Health Professor of Cardiovascular Diseases at the University of Cambridge, affiliated with the Victor Phillip Dahdaleh Heart & Lung Research Institute. He is a leading researcher in cardiovascular immunology, focusing on the interplay between cell death, inflammation, and disease progression.

• University: University of Cambridge
• Institute: Victor Phillip Dahdaleh Heart & Lung Research Institute
• Academic Rank: Professor

His research explores mechanisms of inflammation in cardiovascular diseases, particularly the role of interleukin-1 (IL-1) in atherosclerosis, cellular senescence, and immune dysfunction. Key projects include targeting senescent cell-driven vascular inflammation, understanding clonal hematopoiesis in atherogenesis, and dissecting macrophage polarization effects on IL-1 signaling.

Recent publications highlight his work on thrombin-activated IL-1α in atherogenesis, non-canonical inflammasome control of the senescence-associated secretory phenotype (SASP), and T cell-intrinsic complement-IL-1R2 axis regulation of immune responses. These studies span immunology, cardiovascular biology, and aging research, emphasizing novel therapeutic targets for inflammatory diseases.

Professor Clarke employs cell culture, animal models, and advanced immunoassays to investigate inflammasome activation, IL-1 signaling aberrations, and senescence in disease contexts. His group has identified molecular pathways linking cell death to adaptive immunity, with implications for multiple chronic conditions.