About
Mitchell B. Schaffler is a CUNY Distinguished Professor and Wallace H Coulter Professor in the Biomedical Engineering department at City University of New York (CUNY). He conducts research on osteocyte biology, bone mechanosignaling, and skeletal aging mechanisms.
- Email: mschaffler@ccny.cuny.edu
Research Interests focus on:
- Osteocyte calcium signaling dynamics under mechanical loading
- Role of mitochondrial dysfunction in skeletal aging
- Hormonal regulation (GH/IGF, estrogen) of bone metabolism
- Impact of diabetes on bone mechanosignaling
- Microdamage repair mechanisms in cortical and trabecular bone
Scientific Contributions include:
- Developing intravital imaging techniques for studying bone cell signaling
- Elucidating purinergic signaling pathways in osteocyte apoptosis
- Investigating bisphosphonate mechanisms in bone protection
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