Misty Riddle

Misty Riddle is an Assistant Professor in the Department of Biology at the University of Nevada, Reno. Her research focuses on understanding how genetic changes alter development and drive the evolution of morphology and physiology using the Mexican tetra (Astyanax mexicanus) as a model organism.

• Ph.D. in Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara (2013)
• B.S. in Biology, Westminster College, Utah (2008)

Her lab investigates cave-dwelling populations of Astyanax mexicanus, which have evolved unique adaptations such as eye loss, reduced pigmentation, and metabolic changes (e.g., insulin resistance) to survive in perpetual darkness and nutrient-scarce environments. Key projects include:

• Genetic mapping of metabolic and craniofacial traits
• Comparative genomics and transcriptomics analysis
• Gene-editing studies on developmental and physiological adaptations

The lab integrates multidisciplinary approaches to explore:

• Vitamin A metabolism evolution
• Gut microbiome composition differences
• Enteric nervous system development
• Gastrointestinal homeostasis

Her publications highlight collaborations with leading researchers and span topics from cavefish genetics to developmental biology in C. elegans. Lab members engage in community-building activities, including annual retreats and symposium participation.