Michel H.M. Eppink

Prof. Dr. Michel H.M. Eppink is a Special Professor in “Industrial Biopharmaceutical Downstream Processing” at the Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology. With over 35 years of experience in biomolecule processing, he brings extensive industry expertise from Organon NV and Byondis BV to his academic role. His current position is part-time (0.2 FTE), focusing on integrating harvesting, cell disruption, extraction, separation and formulation technologies for biopharmaceuticals.

His research interests include developing lean production processes for biopharmaceuticals with emphasis on green technologies, circular economy principles, and cost reduction in medicine production. He specifically investigates fractionation technologies and process integration for biopharmaceutical proteins including monoclonal antibodies and antibody-drug conjugates. His work addresses bottlenecks in process robustness, efficiency, product quality, and waste reduction.

Prof. Eppink has received his MSc in Biology/Chemistry from Utrecht University (1993) and PhD in Biochemistry from Wageningen University (1999). Before joining TU Delft in 2024, he served as part-time Professor at Wageningen University from 2014-2024, leading research on biorefinery technologies for proteins, lipids, carbohydrates and pigments from various eukaryotic organisms.

His recent publications focus on chromatography optimization and digital twin applications in biopharmaceutical process development, reflecting his expertise in improving efficiency and sustainability in biomanufacturing processes. These works demonstrate trends toward continuous processing, high-throughput screening, and data-driven optimization in downstream biopharmaceutical production.

Prof. Eppink actively contributes to education through advanced courses in Bioprocess Design and Downstream Processing at the Biotechnology Academy Delft, as well as lectures at Wageningen University, Leiden University, Utrecht University, Karlsruhe Institute of Technology, Radboud University, and Maastricht University.

His office is located in Building 58, room C2.150 at TU Delft, and he can be reached at M.H.M.Eppink@tudelft.nl or +31 683169622.