Michael Shiloh

Michael Shiloh, M.D., Ph.D., is an Associate Professor with tenure in the Departments of Internal Medicine and Microbiology at UT Southwestern Medical Center. He holds the James P. Luby, M.D. Professorship in Infectious Diseases and is a member of the Division of Infectious Diseases and Geographic Medicine. Dr. Shiloh serves on the Biosafety Committee and Medical Scientist Training Program Steering Committee at UT Southwestern.

He earned a B.S. in Chemistry from Pennsylvania State University, followed by an M.D. and Ph.D. in Immunology from Cornell University. He completed residency training in Internal Medicine, a fellowship in Infectious Diseases, and a Molecular Medicine fellowship at the University of California San Francisco.

His research focuses on Mycobacterium tuberculosis pathogenesis, integrating molecular genetics, cell biology, and metabolomics to investigate host-pathogen interactions. Key areas include:

• Mechanisms of mycobacterial entry and immune evasion
• Role of autophagy and ubiquitin signaling in host defense
• Neuronal activation and cough induction pathways
• Development of novel vaccines and therapeutics

His laboratory employs advanced techniques like lung-on-a-chip models and single-cell transcriptomics to study infection mechanisms.

Honors include:

• James P. Luby, M.D. Professorship in Infectious Diseases
• Election to the American Society of Clinical Investigation

He leads the Shiloh Lab, focusing on integrated approaches to tuberculosis research using molecular, bioinformatic, and metabolomic tools.