Michael R. Sperling

Michael R. Sperling, MD, serves as the Baldwin Keyes Professor in the Department of Neurology at Thomas Jefferson University's Sidney Kimmel Medical College in Philadelphia. He is a core faculty member directing research at the Jefferson Comprehensive Epilepsy Center, a multidisciplinary unit comprising ten faculty specialists.

His research program investigates critical dimensions of epilepsy through advanced clinical methodologies:

• Novel therapeutic interventions and pharmacologic studies of antiepileptic drug metabolism
• Autonomic nervous system effects during seizures including cardiac rhythm disturbances
• Electrophysiological mapping of seizure propagation networks
• Neuroimaging analysis of brain connectivity, memory, and language organization
• Long-term surgical outcome assessment across cognitive and psychosocial domains
• Epidemiological studies of mortality risks in epilepsy

Recent publications demonstrate interdisciplinary integration of EEG, fMRI, and clinical metrics to characterize seizure dynamics, drug effectiveness, and brain energy patterns. His work emphasizes translational applications for improving prognostication and personalized treatment strategies in epilepsy care.

Dr. Sperling collaborates within a dedicated ten-physician research team at the Jefferson Comprehensive Epilepsy Center, advancing both clinical protocols and fundamental understanding of epileptic mechanisms through coordinated multimodal investigations.