Michael Peluso

Michael Peluso, MD is an Assistant Professor at the University of California, San Francisco, specializing in infectious disease research with a primary focus on HIV cure strategies and Long COVID. His work spans clinical and laboratory investigations aimed at understanding disease mechanisms and developing novel interventions for patients affected by these conditions.

Dr. Peluso's research interests include HIV reservoir dynamics and implementing clinical trials to disrupt the reservoir with the aim of inducing antiretroviral therapy-free HIV remission. For Long COVID, he manages a comprehensive research program including the Long-term Impact of Infection with Novel Coronavirus (LIINC) observational cohort, tissue collection programs (gut, lymph node, cerebrospinal fluid, bone marrow), imaging studies, and clinical trials for Long COVID interventions. His research has significantly advanced understanding of immune dysregulation, biomarker identification, and therapeutic approaches for post-acute sequelae of SARS-CoV-2 infection.

Analysis of his recent publication portfolio reveals consistent contributions across multiple domains of HIV cure research and Long COVID pathogenesis. His work demonstrates sophisticated approaches to understanding viral reservoirs, immune responses, and clinical manifestations of these conditions, with particular emphasis on translational applications that could lead to improved patient outcomes.

• His HIV research focuses on analytical treatment interruptions and combination immunotherapy approaches
• His Long COVID work examines biomarkers, immune dysregulation, and tissue-based viral persistence
• He actively contributes to the RECOVER Initiative framework for Long COVID research

Dr. Peluso's educational background in both clinical medicine and public health informs his multidisciplinary approach to research, bridging basic science, translational investigation, and clinical application to address complex challenges in infectious disease.