Michael Bottery

Michael Bottery is a Dr Sir Henry Wellcome Fellow at the Division of Evolution, Infection and Genomics, University of Manchester. His work focuses on the evolutionary mechanisms of antimicrobial resistance in bacterial and fungal pathogens, particularly Aspergillus fumigatus and Pseudomonas aeruginosa.

• Research Themes:
  • Evolution of antifungal resistance
  • Plasmid-mediated antibiotic resistance
  • Microbial ecology in clinical and environmental contexts
  • Climate change impacts on fungal disease boundaries

Publications reveal expertise in:

• Antifungal resistance mechanisms (10+ articles)
• Plasmid fitness cost compensation
• Microbial community dynamics in cystic fibrosis
• Environmental drivers of drug resistance
• Climate change and infectious disease spread

Scientific Contributions:

• Developed understanding of A. fumigatus cross-resistance between agricultural fungicides and clinical antifungals
• Advanced knowledge of mutation rate impacts on resistance evolution
• Provided evidence for body heat as a selective pressure in antifungal resistance