Meredith Jackrel

Dr. Meredith Jackrel is an Associate Professor of Chemistry at Washington University in St. Louis specializing in protein misfolding disorders and therapeutic development. Her research program combines:

• Protein engineering of disaggregases
• Directed evolution techniques
• Neurodegenerative disease models
• Molecular chaperone mechanisms

Key accomplishments include developing engineered Hsp104 variants that suppress neurodegeneration in Parkinson's models, with publications in Cell, Science, and Journal of Biological Chemistry. Research integrates biochemical, biophysical, and cellular approaches to reverse pathological protein aggregation.