Melisa Merdanovic

Dr. Melisa Merdanovic is a Researcher at the University of Duisburg-Essen, affiliated with the Faculty of Biology and the Department of Microbiology II. She is part of the Center for Medical Biotechnology (ZMB), contributing to protease research and bacterial protein quality control.

Her research focuses on structural and functional aspects of proteases, including regulation mechanisms, allosteric activation, and substrate interactions. She has extensively studied serine proteases like DegP/DegS in Escherichia coli and their roles in stress response pathways.

Recent work includes developing mouse models for amyloidosis, exploring protein encapsulation via DNA nanotechnology, and investigating nanoparticle-mediated protease delivery. These studies highlight her expertise in bridging bacterial protease dynamics with biomedical applications.

Her publications span high-impact journals such as Nature Communications, PNAS, and Annual Review of Microbiology, emphasizing mechanistic insights and therapeutic implications of protease regulation.