Matthew Paszek

Matthew Paszek is a Professor in the Department of Biomedical Engineering at the University of California, Davis. His research group investigates spatial organization of biomolecules at nanometer scales, focusing on how mechanical forces and biophysical interactions regulate intracellular signaling. A key emphasis is placed on the role of the glycocalyx (cellular sugar coating) in signal transduction and its pathological implications in aggressive cancers.

Research Focus

Professor Paszek's interdisciplinary work integrates:

• Glycobiology: Examining how cell-surface sugars configure signaling machinery
• Cancer mechanisms: Investigating glycocalyx-driven progression to lethal malignancies
• Nanoscale biophysics: Studying energy-dependent spatial arrangements of biomolecules
• Metabolic regulation: Exploring sugar metabolism's role in disease signaling

Methodologies include super-resolution microscopy, computational modeling, and molecular/cellular biology techniques. His lab is currently accepting students pending funding availability.