Matt Reynolds

Matt Reynolds is an Associate Professor in the Department of Pathobiological Sciences at the University of Wisconsin–Madison, School of Veterinary Medicine. His research is centered at the AIDS Vaccine Research Laboratory (AVRL), where he leads innovative studies in immunology and virology to combat HIV/AIDS and related diseases using non-human primate models. He collaborates with key research teams including those of David O’Connor, Shelby O’Connor, and Slukvin.

• Ph.D. in Pathology, University of Wisconsin–Madison (2006)
• B.S. in Medical Microbiology and Immunology, University of Wisconsin–Madison (1998)

Dr. Reynolds’ research focuses on understanding adaptive immune responses to prevent or eliminate AIDS virus infections. His lab develops novel vaccines, cure strategies, and genomic tools to identify tumor neoantigens and minor histocompatibility antigens. A major emphasis is on monoclonal antibody discovery from memory B cells and gene editing approaches to confer resistance to SIV. His work integrates immunology, virology, molecular biology, and genomics to pioneer new therapeutic platforms.

His recent publications reflect a strong trend in developing cutting-edge tools for antibody isolation and gene-edited cell therapies. These studies leverage non-human primate models, particularly Mauritian cynomolgus macaques, to bridge translational gaps in human medicine. His work on CCR5-edited iPSCs and SMART-based antibody amplification demonstrates technological innovation with broad applications in infectious disease and oncology.

Although no formal scientific awards are listed in the provided text, his co-senior authorship on high-impact publications in journals such as Stem Cell Reports and Frontiers in Immunology underscores his leadership in the field.

Dr. Reynolds actively mentors graduate and undergraduate students and welcomes prospective trainees interested in immunology, virology, and molecular biology. His lab is part of a collaborative environment at AVRL, fostering interdisciplinary research. While specific grants are not mentioned, his advanced technological platforms suggest significant external funding support. The lab is located at 585 Science Dr, UW Research Park, and is accessible via public transit.

The Reynolds Lab operates within the AVRL, a dynamic research hub shared with leading virology and immunology labs. This environment promotes collaboration on HIV pathogenesis, vaccine development, and immune monitoring. The lab’s focus on translational tools—such as monoclonal antibodies and gene-edited cell therapies—positions it at the forefront of biomedical innovation.