Mathieu Nollet

Mathieu Nollet is a Research Associate in the Department of Life Sciences at Imperial College London's Faculty of Natural Sciences, affiliated with the UK Dementia Research Institute. His research focuses on the intersection of neurosciences, pharmacology, and clinical sciences, particularly investigating sleep mechanisms, stress responses, and neurodegenerative processes in murine models of depression and chronic stress. He employs advanced techniques like single-cell transcriptomics and behavioral pharmacology to explore molecular and cellular pathways.

Key research themes include: (1) Stress-sleep interaction dynamics, (2) Orexinergic system modulation in depression, (3) Molecular signatures of sleep disorders, and (4) Neuroendocrine stress axis regulation. His work combines neuropharmacology with systems biology approaches to bridge basic science and clinical applications in neurodegeneration and mental health.

Recent studies highlight reciprocal relationships between sleep deprivation and stress, stress-induced sleep circuitry activation, and antidepressant mechanisms targeting orexin receptors. Findings contribute to understanding how chronic stress impacts sleep architecture and neuroprotective pathways, with implications for developing novel pharmacological interventions.

Nollet's research is conducted primarily using rodent models, with emphasis on unpredictable chronic mild stress protocols and translatable biomarker identification. His affiliations include the UK Dementia Research Institute, reflecting his focus on neurodegenerative aspects of sleep disturbances.