Mathangi Gopalakrishnan

Mathangi Gopalakrishnan, PhD, MPharm, is an Associate Professor in the Department of Practice, Science, and Health Outcomes Research at the University of Maryland School of Pharmacy. She is actively engaged in research, mentoring, and academic scholarship, with a focus on quantitative clinical pharmacology and data-driven therapeutic optimization.

Education:

• PhD, Statistics, University of Maryland, Baltimore County
• MS, Statistics, University of Maryland, Baltimore County
• MPharm, Birla Institute of Technology & Science, Pilani, Rajasthan, India
• BPharmacy (Honors), Birla Institute of Technology & Science, Pilani, Rajasthan, India

Her research interests center on pharmacometrics, precision therapeutics, predictive analytics, real-world data, and drug development. She integrates principles of clinical pharmacology, advanced frequentist and Bayesian statistical methods, and artificial intelligence/machine learning to enhance patient outcomes, particularly among vulnerable populations. Her lab's work includes designing prospective clinical pharmacokinetic trials for anti-epileptics and antimicrobials in patients on continuous renal replacement therapy, leveraging real-world data from electronic health records to optimize dosing in neonatal opioid withdrawal syndrome and pediatric anticoagulation, and developing models for disease progression in conditions like schizophrenia and binge-eating disorders.

The trends in her recent publications reflect a consistent focus on model-informed precision dosing, real-world evidence generation, pharmacokinetic-pharmacodynamic (PK/PD) modeling in special populations, and methodological innovation in clinical trial design. Her work spans diverse therapeutic areas including critical care, neonatology, psychiatry, and maternal health, demonstrating a broad impact of quantitative pharmacology.

Dr. Gopalakrishnan is accepting applications for postdoctoral positions in pharmacometrics at the Center for Translational Medicine, indicating active research funding and team leadership. Her collaborations extend to academic medical institutions nationwide, underscoring her role in multi-center research initiatives.

She is involved in collaborative research with academic medical institutions across the country and has presented her work at major conferences including the Joint Statistical Meetings (JSM) and the American Conference on Pharmacometrics (ACoP).