Martin F. Arlt

Martin F. Arlt is an Associate Research Scientist in the Department of Human Genetics at the University of Michigan Medical School. His research focuses on genetic mechanisms underlying cancer, genomic stability, and evolutionary biology. He investigates X/Y chromosome dynamics, replication stress responses, and the role of intrinsically disordered proteins in genetic conflicts. Arlt's work utilizes yeast and mouse models to study evolutionary arms races and their implications in reproduction and disease.

Recent studies include reenacting mouse X/Y chromosome genetic conflicts in yeast, revealing competitive protein interactions, and analyzing how transcription silencing at the FHIT gene suppresses replication stress-induced genomic instability. His research also explores the genomic structure of X chromosome genes and their evolutionary origins in mice.

Publications span journals such as Proceedings of the National Academy of Sciences, Nucleic Acids Research, and Nature Reviews Cancer. His work contributes to understanding cancer mechanisms, genomic instability, and evolutionary adaptations in genetic systems.