Marta Filizola

Marta Filizola, PhD currently serves as Dean of the Graduate School of Biomedical Sciences and holds Professor appointments in both the Department of Pharmacological Sciences and the Department of Neuroscience at the Icahn School of Medicine at Mount Sinai. Her research focuses on computational modeling and structural biology of G protein-coupled receptors (GPCRs) with applications in drug discovery and signal transduction mechanisms.

• Primary Affiliation: Icahn School of Medicine at Mount Sinai
• Roles: Dean, Graduate School of Biomedical Sciences; Professor, Pharmacological Sciences; Professor, Neuroscience

Research Interests span multiple facets of GPCR biology, including:

• Allosteric modulation and biased agonism mechanisms
• Computational approaches for drug design targeting opioid and serotonin receptors
• Structural characterization of integrins and their antagonists
• Integration of molecular dynamics simulations with experimental data
• Development of AI-powered tools for bioactivity prediction
• Investigation of divalent cation effects on receptor function

The most recent publications highlight advancements in GPCR structural modeling and computational drug discovery, including novel strategies for targeting opioid receptors with reduced side effects, insights into saxitoxin neutralization by amphibian proteins, and development of AI frameworks like BOLD-GPCRs for bioactivity predictions. Key themes include allosteric site identification, ligand binding dynamics, and translational approaches to improve pain management and treat neurological disorders.

Contact Information: Email: testemail@address.com