Mark T. W. Ebbert

Mark T. W. Ebbert, PhD, is an Associate Professor at the University of Kentucky's Sanders-Brown Center on Aging, where he leads the Ebbert Lab. His work focuses on developing biomarkers for neurodegenerative diseases, particularly Alzheimer's disease (AD), leveraging cutting-edge genomic and transcriptomic techniques. He co-leads efforts in the Alzheimer's Disease Research Center's Biomarker Core, aiming to integrate neuroimaging, fluid biomarkers, and genomic data for precision medicine applications.

Key research interests include analyzing genetic variants, long-read sequencing for disease resilience, and understanding inflammation's role in neurodegeneration. He has presented at high-profile venues like the Markesbery Symposium, discussing topics such as using long-read sequencing to identify AD biomarkers. His lab has produced over 55 publications, with a focus on resolving genomic 'dark regions' and improving biomarker accuracy through innovative methods like RNApysoforms visualization tools.

Collaborating with interdisciplinary teams, Dr. Ebbert explores the interplay between genetics, epigenetics, and environmental factors in neurodegenerative diseases. His work bridges basic science and clinical translation, emphasizing the importance of genomic data integration for advancing AD diagnosis and treatment strategies.