Mark N. Gillespie

Mark N. Gillespie is a Professor in the Department of Pharmacology at the University of South Alabama's College of Medicine. He previously served as Department Chair from 1995 to 2023 and can be contacted at mgillesp@southalabama.edu.

• Education: Ph.D. in Pharmacology (University of Kentucky), Baccalaureate in Physiology (University of Kentucky)
• Postdoctoral Training: Cardiovascular Pulmonary Research Lab, University of Colorado, Denver

Research Focus: The Gillespie laboratory investigates oxidative injury to mitochondrial and nuclear DNA in lung cells, particularly how mtDNA damage activates cell death pathways and nuclear DNA modifications affect gene regulation. His work spans from cultured lung cells to human tissue models of COPD and pulmonary hypertension.

Publication Trends: Recent articles (2020-2022) highlight his expertise in mitochondrial DNA as a biomarker in traumatic injury, critical care, and transplantation medicine. Key themes include oxidative stress mechanisms, genomic repair strategies, and metabolomic profiling for disease prognosis.

Labs & Teams: Leads research teams at the University of South Alabama Medical Sciences Building, focusing on acute lung injury and pulmonary disorders through genomic and metabolomic approaches.