Mark Iscoe

Mark Iscoe, MD, MHS is an Assistant Professor of Emergency Medicine and Biomedical Informatics and Data Science at Yale School of Medicine. He holds fully joint appointments in both the Department of Emergency Medicine and the Department of Biomedical Informatics & Data Science, reflecting his interdisciplinary work at the critical intersection of clinical emergency care and health informatics innovation.

Dr. Iscoe completed his medical degree at Johns Hopkins University School of Medicine in 2017, followed by residency training in Emergency Medicine at New York University / Bellevue Hospital in 2021. He further specialized with a Master of Health Science (MHS) in Clinical Informatics from Yale School of Medicine in 2023. He is board certified in both Emergency Medicine (2022) and Clinical Informatics (2024).

His research spans several interconnected domains with a focus on optimizing the interface between emergency physicians and health information technology. Key areas include electronic health record (EHR) optimization, artificial intelligence applications in emergency settings, clinical decision support systems, and medication safety protocols. His 2024 JAMA Network Open publication 'Benchmarking Emergency Physician EHR Time per Encounter Based on Patient and Clinical Factors' represents a significant contribution to understanding the digital burden on emergency clinicians. More recently, he has pioneered work applying large language models to emergency medicine challenges, with multiple 2025 publications on AI applications for deprescribing, symptom identification, and risk stratification.

His research trajectory shows a clear evolution from foundational EHR usage studies toward increasingly sophisticated AI implementations that bridge theoretical informatics with practical clinical tools in high-pressure emergency settings.

• YCCI Scholar Award for AI Research on Drug Reactions (2024)

Dr. Iscoe has received research funding from multiple prestigious sources including the National Institute on Drug Abuse (NIDA), the American Medical Association (AMA), the National Institutes of Health, and Yale New Haven Health System. His collaborative network includes prominent researchers such as Andrew Taylor (6 joint publications), Ted Melnick (5 joint publications), and Rohit Sangal (4 joint publications), reflecting his work's multidisciplinary nature spanning clinical departments, informatics specialists, and data scientists.