Maria Kefala

Maria Kefala serves as a Clinical Associate Professor in the Department of Clinical Medicine within the Faculty of Health and Medical Sciences at the University of Copenhagen. Her clinical and research work is anchored in Pathology, with contact details including phone +4546323200 and email mkef@regionsjaelland.dk at Blegdamsvej 3, 2200 København N.

Her research centers on hematologic malignancies, specializing in myeloproliferative neoplasms (MPNs) and clonal hematopoiesis. She investigates disease progression mechanisms—particularly CALR-mutated clonal hematopoiesis evolving into pre-fibrotic myelofibrosis—and develops early detection frameworks for blood cancers using longitudinal and population-based studies. Her work integrates clinical pathology with molecular diagnostics to identify biomarkers for malignant transformation.

Recent publications reveal a focus on translating genomic insights into clinical practice, emphasizing early intervention strategies for MPNs. Her 2023 case report established the first longitudinal evidence of clonal hematopoiesis progression, while her 2021 population study demonstrated scalable screening methods in general cohorts, collectively advancing precision oncology in hematologic malignancies.