Marc de la Roche

Marc de la Roche is a Professor and Group Leader in the Department of Biochemistry at the University of Cambridge. His research focuses on understanding the molecular mechanisms driving colorectal cancer (CRC) through the oncogenic Wnt signaling pathway. Key areas of investigation include the role of the APC tumor suppressor, intestinal epithelial stem cell regulation, and therapeutic targeting of Wnt signaling using organoid models and genetically engineered mouse (GEM) systems.

Research objectives include determining APC’s dual role in Wnt pathway regulation and epithelial polarity, validating oncogenic Wnt as a therapeutic target, and characterizing TCF7L2-mutant CRC subtypes. His group employs organoid cultures and mouse models for in vivo validation of potential treatments.

Publications highlight advancements in immunotherapies targeting LGR5+ stem cells, Hedgehog signaling in T-cell polarization, and molecular inhibitor engineering. Collaborations span cancer biology, immunology, and bioengineering. The lab actively mentors graduate students and postdoctoral researchers, with alumni at institutions like Ludwig-Maximilians-University Munich and the University of Oxford.

Contact: mad58@cam.ac.uk | Sanger Building, Downing Site, Cambridge.