About
Marc Delarue is a Professor and Head of Structure at the Laboratory of Architecture and Dynamics of Biological Macromolecules, part of the Department of Structural Biology and Chemistry at the Institut Pasteur in Paris, France. He leads multiple research projects focused on DNA repair, DNA replication, ion channels, and computational structural biology.
- Institution: Institut Pasteur
- School: Department of Structural Biology and Chemistry
- Department: Architecture and Dynamics of Biological Macromolecules
- Role: Head of Structure, Principal Investigator
His research integrates experimental and computational approaches, including X-ray crystallography, cryo-EM, molecular dynamics, and electrostatic modeling, to understand macromolecular structure-function relationships. Key interests include DNA polymerases, NHEJ repair in cancer, ligand-gated ion channels, and the development of simulation software such as MinActionPath and NOMAD-Ref.
The recent publications highlight a strong trend in structural mechanisms of DNA-processing enzymes, ion channel pharmacology, and computational modeling of macromolecular transitions. These works frequently appear in high-impact journals and involve collaborations across disciplines and institutions.
Marc Delarue has mentored numerous PhD students and postdoctoral researchers, including Jérémie Piton, Jerome Gouge, Frederic Poitevin, and Leonardo Betancurt Anzola. His projects are supported by internal and transversal funding initiatives at the Institut Pasteur, such as the Cancer Initiative and INCEPTION convergence program, though specific grant names are not detailed.
He is actively involved in software development for structural bioinformatics, leading projects like MinActionPath and NOMAD-Ref, which are used to simulate conformational changes and analyze dynamics in large macromolecular complexes.
