Manuela Zaccolo

Manuela Zaccolo is a Professor of Cell Biology at the University of Oxford since 2012 and a Tutorial Fellow in Pre-Clinical Medicine at Balliol College, Oxford, UK. Her research focuses on the spatial and temporal regulation of cyclic nucleotide signaling, particularly in cardiac pathophysiology.

Research Interests:

• Cyclic nucleotide signaling (cAMP/cGMP)
• Subcellular compartmentalization of signals
• Role of phosphodiesterases in heart disease
• AKAP-mediated signal transduction
• Quantitative optical imaging in living cells

Scientific Contributions: She pioneered genetically encoded FRET-based reporters for cyclic AMP, enabling real-time monitoring of signaling in live cells. Her work on compartmentalized signaling in cardiac myocytes has redefined understanding of second messenger systems.

Scientific Awards & Honors:

• Fellow of the Istituto Veneto di Scienze, Lettere ed Arte (2023)
• Fellow of the Royal Society of Biology (2019)
• Royal Society Wolfson Merit Award (declined, 2011)
• Telethon Career Award (2001-2007)
• Royal Society/Accademia dei Lincei European Science Exchange Fellowship (1996-1997)
• British Council Grant in Aid (1992)