Manish Sadarangani

Dr. Manish Sadarangani is an Associate Professor in the Department of Pediatrics at the University of British Columbia's Faculty of Medicine. He serves as the Director of the Vaccine Evaluation Center at BC Children's Hospital and holds the prestigious Sauder Family Chair in Pediatric Infectious Diseases. His research program spans multiple affiliations including Experimental Medicine, Microbiology and Immunology, and Women+ and Children's Health Sciences programs. Dr. Sadarangani leads research initiatives through the Vaccine Evaluation Center, which focuses on reducing childhood infectious disease burden through evidence-based vaccine policy development.

Dr. Sadarangani's research interests encompass a broad spectrum of vaccine-related science including antimicrobial resistant bacteria, bacterial vaccines, childhood infections, epidemiology, immune system responses, and vaccine development and immunity. His work integrates clinical trials, observational studies, and laboratory investigations to address critical questions in pediatric infectious diseases. His research has particular emphasis on vaccine safety, effectiveness, and implementation strategies across diverse populations, including Indigenous communities and immunocompromised children.

Analysis of Dr. Sadarangani's recent publications reveals a strong focus on vaccine safety monitoring (particularly for mRNA COVID-19 vaccines in children), respiratory infections (including RSV and pneumococcal disease), meningitis diagnostics, and antimicrobial resistance. His work often addresses health disparities, with publications examining healthcare outcomes in Indigenous populations and strategies to overcome language barriers in clinical research. The research demonstrates methodological diversity, incorporating randomized controlled trials, large observational studies, systematic reviews, and qualitative approaches.

• Investigator at BC Children's Hospital Research Institute
• Member of Action on Sepsis research cluster
• Member of PREVENT-AMR: Prevention of AMR via a One Health Approach
• Member of Women's Health Research Institute

Dr. Sadarangani actively collaborates on interdisciplinary research projects and expresses interest in working with undergraduate students on research initiatives. His Vaccine Evaluation Center serves as a hub for vaccine-related research that informs local, national, and international vaccine policy decisions through rigorous scientific investigation.