Lukas Dow

Lukas Dow is a Professor at the Weill Cornell Medicine Graduate School of Medical Sciences, where he leads an active research laboratory focused on colorectal cancer. His lab is affiliated with the Cell & Developmental Biology PhD program and operates at the Belfer Building, 413 East 69th Street, New York, NY 10021.

His research centers on understanding the genetic and environmental drivers of colorectal cancer initiation, progression, and therapeutic response. The Dow Lab employs in vivo animal models and ex vivo organotypic cultures, leveraging advanced technologies such as regulated miRNA-based shRNAs and CRISPR/Cas9 genome editing to generate precise pre-clinical models based on human cancer genetics.

Key research areas include:

• Cancer Biology
• Cell Differentiation
• Signal Transduction
• Stem Cells
• Genetic Context in Tumor Development
• Inflammatory Microenvironment Effects

The lab collaborates extensively with researchers at Memorial Sloan Kettering Cancer Center and Cold Spring Harbor Laboratory to pioneer next-generation tools for cancer modeling. These efforts aim to identify critical cancer drivers and develop more effective treatment strategies tailored to individual genetic profiles.

Lukas Dow advises graduate students through the PhD program in Cell & Developmental Biology. While specific grant funding is not listed, his research program implies substantial support for molecular oncology and translational cancer research.

The Dow Lab maintains a strong presence in cancer research innovation, with ongoing work in developing genetically engineered models and dissecting tumor-stroma interactions. The lab also emphasizes training and development, as reflected in its structured organization and outreach activities.