Loic Binan

Loic Binan is an Assistant Professor in the Department of Human Genetics at McGill University, with additional affiliations as an Associate Member in the Department of Biomedical Engineering and the Integrated Program in Neuroscience. His research focuses on developing cutting-edge technologies to investigate how gene networks control the self-organization of cells into complex 3D tissues during development and in disease conditions.

Dr. Binan's research interests span multiple interdisciplinary fields, with particular emphasis on cancer metastasis, where he investigates the genetic mechanisms allowing cells to reversibly transition between epithelial and mesenchymal phenotypes. His work also explores isoforms and non-coding regions, developing technologies to understand alternative splicing in neurodegenerative diseases, and examining how past cell-cell interactions shape present transcriptional activity during development.

His laboratory employs a diverse array of techniques including CRISPR gene editing, spatial transcriptomics, single-cell RNA sequencing, advanced microscopy, and computational methods for image analysis. The recent publications reveal a strong trend toward integrating high-throughput genetic screening with spatial transcriptomics to map gene regulatory networks across both cancer biology and neuroscience contexts.

Dr. Binan leads the Binan Lab at the Lady Davis Institute for Medical Research, where his team develops precision gene editing tools such as Cas9 and Cas12 for high-throughput screens, creates novel imaging tools to collect spatial context data, and builds computational tools to analyze these complex new data types. His research primarily focuses on cancer and neurodegenerative diseases, with particular attention to brain development and tumor microenvironments.