Lingbo Zhang

Dr. Lingbo Zhang is Assistant Professor in the Department of Pathology & Immunology at Cold Spring Harbor Laboratory, where he directs the Zhang Laboratory and serves as Faculty Head of the Flow Cytometry Shared Resource. He holds a Ph.D. from the joint MIT-NUS program where he trained under Dr. Harvey Lodish.

His research focuses on metabolic and neuronal regulation of hematopoietic stem/progenitor cells and hematologic malignancies. Key areas include:

• Nutrient dependencies in leukemia stem cells
• Neuronal signaling in hematopoietic regeneration
• Metabolite-driven oncogenic pathways
• Vitamin B6 addiction mechanisms in AML

Recent publications demonstrate consistent focus on metabolic vulnerabilities in myeloid malignancies and neuronal regulation of erythropoiesis. His team utilizes CRISPR screening, metabolomics, and preclinical models to identify therapeutic targets.

Awards include NIH MERIT and EvansMDS Young Investigator Awards recognizing his work on metabolic dependencies in hematologic cancers.

He mentors 15+ trainees and leads collaborations with medicinal chemists to develop first-in-class therapeutics targeting metabolic pathways.