Leslie R Harrold

Leslie R Harrold, MD, MPH, is an Associate Professor at UMass Chan Medical School in the Department of Medicine. She specializes in rheumatology, focusing on real-world effectiveness of biologics and targeted therapies for rheumatoid arthritis, gout, and psoriatic arthritis. Her work leverages large clinical registries and epidemiological methods.

Education:

• BA in Biology, Mount Holyoke College
• MD, University of Massachusetts Medical School
• MPH in Public Health, University of Massachusetts Amherst

Her research explores:

• Comparative effectiveness of biologics (abatacept, TNF inhibitors, JAK inhibitors)
• Impact of comorbidities (obesity, metabolic syndrome) on treatment outcomes
• Health disparities across racial and ethnic groups
• Adherence to gout and rheumatoid arthritis therapies
• Cardiovascular risk in inflammatory arthritis patients

Key trends in her 15 most recent publications (2025-2019) include:

• Analysis of disease activity biomarkers (ACPA, anti-CCP) in predicting therapeutic response
• Long-term safety profiles of biologic DMARDs
• Population-level studies using Corrona Registry data
• Development of gout treatment consensus criteria