Lennart Brewitz

Dr Lennart Brewitz is a Lecturer in Chemistry at Jesus College, University of Oxford. He holds a PhD from the Technical University of Dortmund (2011-2014) and an M.Sc. from the Technical University of Munich (2006-2011). His research focuses on enzymology, drug discovery, and the development of inhibitors targeting viral and human enzymes, particularly SARS-CoV-2 proteases and hypoxia-inducible factor (HIF) pathways.

Academic Background:

• PhD (Chemistry): Technical University of Dortmund (with Prof. Alois Fürstner)
• M.Sc. (Chemistry): Technical University of Munich

Research Interests:

• Structure-activity relationships of SARS-CoV-2 protease inhibitors
• Therapeutic applications of prolyl hydroxylase inhibitors in oncology
• Biochemical mechanisms of oxygen-dependent hydroxylases
• Design of macrocyclic peptides for antiviral drug delivery

Recent work (2023–2025) emphasizes discovery of potent inhibitors against SARS-CoV-2 main protease and papain-like protease, with notable contributions to understanding enzyme selectivity and hypoxia signaling pathways. His methods include activity-based proteomics and mass spectrometry-based assays.

No scientific awards or grants are explicitly mentioned in the provided texts. No student advisees are listed, though he contributes to undergraduate organic chemistry teaching at Jesus College.

His research is affiliated with the Department of Chemistry at the University of Oxford, leveraging interdisciplinary approaches in medicinal chemistry and enzymology.