LeeAnn Higgins

LeeAnn Higgins is a Researcher at the Center for Metabolomics and Proteomics at the University of Minnesota. With over 25 years of research activity (since 1995), her work spans proteomics, mass spectrometry, and host-microbe interactions, particularly in clinical contexts like cystic fibrosis and pulmonary hypertension.

• Key research areas: Ferroptosis, SERPINE1 gene mutations, and aerolysin-based nanobody engineering
• Recent collaborations focus on metaproteomics workflows and cystic fibrosis disease modeling
• Contributions to UN Sustainable Development Goals through biomedical research

Selected publications demonstrate expertise in:

• 2025: Ferroptosis inhibition mechanisms in cardiac function
• 2025: SERPINE1 mutation analysis in canine models
• 2024: Notch signaling inhibition using pore-forming toxins
• 2024: Ferroptosis-driven inflammation in pulmonary hypertension
• 2022: Optimized proteomics workflows for bronchoalveolar lavage fluid

Research trends show integration of:

• Mass spectrometry techniques
• Metaproteomics for host-microbe dynamics
• Translational approaches across veterinary and human medicine

Contact: higgi022@umn.edu