Lee Tih-Shih

Lee Tih-Shih is a Professor in the Signature Research Programme in Neuroscience & Behavioural Disorders at Duke-NUS Medical School. He holds academic appointments as an Associate Professor at Duke University and clinical privileges at Singapore General Hospital (20% FTE), where he leads the Neuropsychiatry Subspecialty Clinic. His research focuses on neuropsychiatric disorders, cognitive training using brain-computer interface (BCI) technologies, and precision medicine for conditions like ADHD and autism spectrum disorder (ASD). He established Duke-NUS’s Neurocognitive Genomics and Brain-Computer Interface Laboratories, pioneering BCI-based therapies for neurodevelopmental and cognitive disorders.

Education:

• BS (Honors), Northwestern University
• MD, Yale University
• PhD (Genomic and Pathophysiological Characterization of Temporal Lobe Epilepsy), Yale University
• MSc (Psychological Medicine), University of New South Wales

Professional Contributions:

• Deputy Chief Examiner for Psychiatry, Ministry of Health Singapore (2014)
• Inaugural Chair of the Section of Neuropsychiatry at the Academy of Medicine Singapore (2017–2021)
• Board certifications: American Board of Psychiatry and Neurology, Fellow of Royal College of Physicians (Canada & Edinburgh)

Research Interests: His work integrates BCI systems with neuroimaging and wearable devices to address attention deficits, memory disorders, and ASD. Recent studies explore home-based BCI therapies for children with co-occurring ASD and ADHD, as well as sleep behavior analysis using multi-modal data. His lab’s innovations have led to pilot trials for elderly cognitive training and epilepsy gene expression profiling.

Awards:

• Duke-NUS Pioneer Award (2016) for advancing translational research
• Duke-NUS Teaching Award (2008) for excellence in medical education

Teaching & Mentorship: Engages in clinical teaching at Duke-NUS, mentoring medical students and specialist trainees. His educational initiatives include team-based learning and bedside neurology training.

Labs & Collaborations: Leads the Brain-Computer Interface Laboratory, collaborating with institutions like SingHealth and the National University of Singapore on neurotechnology and precision medicine projects.