Lars Küpfer

Univ.Prof.Dr.rer.nat. Lars Küpfer is a Professor at the Institute for Systems Medicine with focus on Organinteraction at RWTH Aachen University Hospital. His research combines physiologically-based pharmacokinetic (PBPK) modelling at whole-body level with systems biology effect models at cellular/tissue scale, particularly studying the gut-liver-axis and quantitative systems pharmacology/toxicology.

He has a strong background in chemical engineering (TH Karlsruhe, RWTH Aachen, Carnegie Mellon University) and computational systems biology from his PhD work at ETH Zurich on yeast metabolism. Since 2005 at Bayer AG and 2011 at RWTH Aachen, he has developed multiscale models for drug development applications.

• Current focus areas: PBPK modelling, systems biology of human/microbial metabolism, drug-induced toxicity prediction
• Recent article trends show specialization in liver/kidney pharmacokinetics, metabolic disease biomarkers, and cross-species drug translation
• Key collaborations include Bayer AG, PortaCellTec, EU-STANDS4PM consortium, and HeCaToS

He actively mentors students and researchers like Ömer Faruk Bay, René, Ravi Jairam, and Ahenk Zeynep Sayin in systems medicine projects.