Larry Alexander

Larry Alexander, PhD is an Associate Professor in the Professional & Medical Education department within the School of Medicine at Meharry Medical College. His research focuses on renal physiology and molecular mechanisms of kidney disease, with particular expertise in obstructive nephropathy and related signaling pathways.

Education:

• Bachelor of Arts in Molecular Biology and Biochemistry from Hendrix College (1985)
• PhD in Physiology from Meharry Medical College School of Graduate Studies and Research (1995)

Research Focus:

Dr. Alexander's research program investigates angiotensin II-AT2-PLA2-arachidonic acid signaling pathways in renal tubular epithelial cells and their role in disease processes such as inflammation, apoptosis, and fibrosis. He has particular expertise in the role of 20-HETE inhibitors and epoxyeicosatrienoic acids in the treatment of renal injury. His work bridges basic science with potential therapeutic applications for chronic kidney diseases.

Publication Trends:

Dr. Alexander's publication record demonstrates a consistent focus on renal cell signaling pathways, particularly examining how mechanical stress (cyclic stretch) and biochemical factors (angiotensin II) influence cellular responses in kidney tissue. His research connects molecular mechanisms with clinical manifestations of kidney disease, with particular emphasis on fibrotic processes.

Research Program:

Dr. Alexander maintains an active research program investigating cellular and molecular mechanisms of kidney disease. His laboratory employs both in vitro and in vivo approaches, including genetic transgenic models, to elucidate disease mechanisms. His research has significant implications for developing novel therapeutic principles for chronic kidney diseases.