Kristin Knouse

Kristin Knouse is the Whitehead Career Development Professor and Assistant Professor of Biology at MIT, affiliated with the Koch Institute for Integrative Cancer Research. She leads the Knouse Lab, focusing on organ regeneration and cancer metastasis. Her research employs CRISPR-based technologies for high-throughput genetic screening in vivo. She holds an MD-PhD from Harvard-MIT programs (2010–2018).

Education: BS in Biology from Duke University (2010), PhD in Biology from MIT (2016), MD from Harvard-MIT (2018). Research expertise spans liver regeneration, cancer dormancy, and chromosomal instability. Key awards include the NIH Early Independence Award (2018).

Research emphasizes leveraging tissue-specific regeneration mechanisms to combat diseases. Recent work includes genome-wide CRISPR screens in mouse livers and studies on centromere maintenance in quiescent cells. Collaborates broadly, with publications in Cell, Genome Research, and Nature Reviews.

Labs/Teams: Knouse Lab at MIT focuses on developing tools for in vivo genetic perturbation and studying metastasis. Active in MIT's Koch Institute and Whitehead Institute.