Ke Shi

Ke Shi is a Research Professional 6 in the Department of Biochemistry, Molecular Biology, and Biophysics (BMBB) at the University of Minnesota with an extensive research portfolio spanning structural biology, virology, and molecular mechanisms of host-pathogen interactions. With 95 documented research outputs and significant contributions to high-impact publications in journals like Nature and Nature Communications, Dr. Shi has established expertise in X-ray crystallography and structural analysis of viral proteins and host defense mechanisms.

Research interests include:

• Structural Biology and X-ray Crystallography
• SARS-CoV-2 and coronavirus structural biology
• APOBEC3 enzyme structure and function
• RNA-protein interactions
• DNA deamination mechanisms in antiviral defense and cancer
• Retroviral integration mechanisms

Analysis of publication trends reveals Dr. Shi's significant contributions to understanding viral structures and host defense mechanisms, with landmark papers on SARS-CoV-2 receptor recognition (Nature, 2020) and neutralization mechanisms (Nature Communications, 2021). Earlier work focused on retroviral integration and APOBEC3 enzyme function, demonstrating consistent expertise in applying structural biology to critical virology questions.

Dr. Shi contributed to the NIH NIGMS-funded "APOBEC3 STRUCTURAL STUDIES" project (2016-2020) as a key research team member, working with Principal Investigator Reuben Harris and Co-Investigator Hiroshi Aihara. Research activity has remained consistently high, with publications spanning from 1999 to projected 2025 outputs, indicating ongoing active research in structural virology and molecular biology.