Karl Sotlar

Karl Sotlar is a Professor and Department Chair at the Institute of Pathology. His research focuses on hematologic malignancies, particularly systemic mastocytosis and breast cancer, with expertise in molecular pathology and translational oncology. He has led clinical studies on immunotherapy combinations and contributed to diagnostic criteria harmonization for mastocytosis. His work spans over 90 publications since 2015, emphasizing tumor biology and clinical applications. Collaborations include multi-institutional trials and genomic analyses in cancer subtypes.

• Roles: Professor, Department Chair
• Affiliation: Institute of Pathology
• Key Research: Mastocytosis, HER2-positive breast cancer, epigenetic mechanisms in lung cancer

Research interests integrate clinical pathology with molecular diagnostics, addressing unmet needs in oncology. Recent work includes neoadjuvant immunotherapy trials and genomic profiling of PD-L1-negative tumors. His studies have been cited widely and adopted into clinical guidelines.