Karim Rafie

Dr. Karim Rafie is an Assistant Professor in Molecular Pharmacology at the Faculty of Science and Engineering, University of Groningen. His research focuses on host-pathogen interactions, structural biology, and virology. He investigates viral entry mechanisms, enzymatic processes in posttranslational modifications (e.g., O-GlcNAc transferase), and drug delivery systems using extracellular vesicles. His work contributes to understanding infectious diseases, neurodegenerative mechanisms, and therapeutic development.

Research Interests:
- Structural biology of viral pathogens (e.g., adenoviruses)
- Enzyme inhibitors and ligase activity modulation
- Extracellular vesicle-based drug delivery
- O-GlcNAc glycosylation and its biological roles

Recent Articles:
Dr. Rafie’s publications highlight advancements in viral capsid structure determination, enzymatic mechanisms (e.g., E3 ligases, O-GlcNAc transferase), and applications of extracellular vesicles in medicine. His 2025 studies address calcium signaling in neuronal death and inhalable dry powder formulations, reflecting his interdisciplinary approach to pharmacology and biomedicine.

Labs/Teams:
Affiliated with the Groningen Research Institute of Pharmacy, focusing on molecular pharmacology and structural enzymology.