Jürg Müller

Jürg Müller is a Researcher at the Max Planck Institute for Biochemistry, leading the Chromatin Biology group. His work focuses on the biochemical mechanisms of chromatin-modifying enzymes and their role in gene transcription regulation.

• Research Overview: Investigates Polycomb/trithorax group proteins, histone modifications, and chromatin structure in Drosophila development.
• Key Techniques: Integrates biochemistry, structural biology, genetics, and genomics.

Research Interests:

• Chromatin structure and function
• Propagation of repressed chromatin states
• Structural analysis of chromatin-modifying complexes
• Role of histone ubiquitination/deubiquitination
• Epigenetic regulation in development and disease
• Mechanistic analysis of Polycomb/trithorax systems

Scientific Trends: Recent publications analyze histone modification crosstalk, PRC2/PRC1 complex dynamics, and stoichiometric relationships in chromatin regulation. Structural insights reveal molecular mechanisms of nucleosome recognition and enzymatic activation.

Team Members: Collaborations include postdocs (Jacques Bonnet, Deepali Bobade), PhD students (Maria Ciapponi, Beyza Dedeoglu), Master students (Berfin Yesil), and research assistants (Petra Lee, Ulrike Goldschmitt).