Jurgen Naggert

Jurgen Naggert is a Professor at the Graduate School of Biomedical Science and Engineering (University of Maine). His research focuses on genetic mechanisms underlying metabolic syndrome, particularly Alström syndrome - a rare condition combining obesity, retinal degeneration, diabetes, cardiomyopathy, and kidney disease. His work explores gene-environment interactions in metabolic disorders and genetic modifiers of retinal disease.

• University of Maine
• Graduate School of Biomedical Science and Engineering
• Professor

Research Interests include:

• Alström syndrome (human gene ALMS1)
• Retinal degeneration and photoreceptor cell loss
• Genetic basis of obesity and type 2 diabetes
• Lysosomal trafficking and cell adhesion
• Gene-environment interactions in metabolic diseases
• Ciliopathies and neurosensory degeneration

Recent articles (2025-2018) examine:

• Mouse models for posterior microphthalmia
• Genetic modifiers of retinal disease
• Role of EML1 in retinal lamination
• SLC4A5 splicing mutations
• Lysosomal dysfunction in retinal adhesion
• Alström syndrome's multi-organ pathology